KMID : 0616120160470030287
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Korean Journal of Pharmacognosy 2016 Volume.47 No. 3 p.287 ~ p.294
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Screening of 50 Korean Herbal formulas with Inhibitory Effects on Acetylcholinesterase Activity and Amyloid-¥â Aggregation
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Lim Hye-Sun
Kim Yoon-Ju Kim Ohn-Soon Jeong Soo-Jin
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Abstract
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Acetylcholinesterase (AChE) activation and amyloid-¥â (A¥â) aggregation are major biological markers of Alzheimer¡¯s disease. In the present study, we evaluated the inhibitory effects of 50 kinds of herbal formulas on AChE activity and A¥â aggregation. Among them, Hwanglyeonhaedok-tang, Cheonwangbosim-dan, Makmundong-tang, and Gamisoyo-san had a potent effects on the inhbition of AChE activity. Sosiho-tang, Samsoeum, Cheonsimyeunjaeum, and Bunsimgieum exerted to have the inhibitory activity on A¥â aggregation. In addition, these 8 herbal formulas showed the 3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity, indicating their antioxidant activities.
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KEYWORD
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Dementia , Acetylcholinesterase , Amyloid-¥â , Antioxidant , Herbal formula
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